Zentrale Schmerzverarbeitung bei chronischem Rückenschmerz: Hinweise auf verminderte Schmerzinhibition

Publikation: Beitrag in FachzeitschriftForschungsartikelBeigetragenBegutachtung

Beitragende

  • T. Giesecke - , Universität zu Köln (Autor:in)
  • R. H. Gracely - , University of Michigan, Ann Arbor (Autor:in)
  • D. J. Clauw - , University of Michigan, Ann Arbor (Autor:in)
  • A. Nachemson - , Georgetown University, University of Gothenburg (Autor:in)
  • M. H. Dück - , Universität zu Köln (Autor:in)
  • R. Sabatowski - , Universität zu Köln (Autor:in)
  • H. J. Gerbershagen - , Universität zu Köln (Autor:in)
  • D. A. Williams - , University of Michigan, Ann Arbor (Autor:in)
  • F. Petzke - , Universität zu Köln (Autor:in)

Abstract

Introduction. A study of patients with low back pain (LBP) had revealed altered central pain processing. At an equal pain level LBP patients had considerably more neuronal activation in the somatosensory cortices than controls. In a new analysis of this dataset, we further investigated the differences in central pain processing between LBP patients and controls, looking for possible pathogenic mechanisms. Methods. Central pain processing was studied by functional magnetic resonance imaging (fMRI), using equally painful pressure stimuli in a block paradigm. In this study, we reanalyzed the fMRI data to statistically compare pain-elicited neuronal activation of both groups. Results. Equally painful pressure stimulation resulted in a significantly lower increase of regional cerebral blood flow (rCBF) in the periaqueductal gray (PAG) of the LBP patients. The analysis further revealed a significantly higher increase of rCBF in LBP than in HC in the primary and secondary somatosensory cortex and the lateral orbitofrontal cortex (LOFK), elicited by these same stimuli. Conclusions. These findings support a dysfunction of the inhibitory systems controlled by the PAG as a possible pathogenic mechanism in chronic low back pain.

Details

OriginalspracheDeutsch
Seiten (von - bis)411-417
Seitenumfang7
FachzeitschriftSchmerz
Jahrgang20
Ausgabenummer5
PublikationsstatusVeröffentlicht - Sept. 2006
Peer-Review-StatusJa
Extern publiziertJa

Externe IDs

PubMed 16586062

Schlagworte

Schlagwörter

  • Echoplanar imaging, Fibromyalgia, Low back pain, Pressure pain, Psychophysic pain sensory testing