X chromosomal recombination--a family study analysing 39 STR markers in German three-generation pedigrees

Publikation: Beitrag in FachzeitschriftForschungsartikelBeigetragenBegutachtung

Beitragende

  • Sandra Hering - , Institut für Rechtsmedizin (Autor:in)
  • Jeanett Edelmann - , Universität Leipzig (Autor:in)
  • Christa Augustin - , Universitätsklinikum Hamburg-Eppendorf (UKE) (Autor:in)
  • Eberhard Kuhlisch - , Institut für Medizinische Informatik und Biometrie (Autor:in)
  • Reinhard Szibor - , Otto-von-Guericke-Universität Magdeburg (Autor:in)

Abstract

Typing of polymorphisms on the human chromosome X (ChrX) has become a standard technique in forensic genetics, and a growing number of short tandem repeats (STRs) has been established. Knowledge of marker recombination is of great significance especially when ChrX typing is used in forensic kinship testing. It is known that meiotic recombination is not a simple function of physical distance but crossing over events tend to be clustered. Information on genetic distances between markers can be gathered by family studies and by interpolation of gene bank data such as the Rutgers map. We typed DNA samples of pedigrees consisting of mothers with several sons and grandfather-mother-son constellations and report here the recombination characteristics of 39 ChrX STRs in up to 135 meioses.

Details

OriginalspracheEnglisch
Seiten (von - bis)483-491
Seitenumfang9
FachzeitschriftInternational journal of legal medicine
Jahrgang124
Ausgabenummer5
PublikationsstatusVeröffentlicht - 2010
Peer-Review-StatusJa

Externe IDs

researchoutputwizard legacy.publication#35795
researchoutputwizard legacy.publication#37083
Scopus 79952197480
PubMed 19936774

Schlagworte

ASJC Scopus Sachgebiete