A multidisciplinary use-case for integrating research data involves data, software and methods across research disciplines to address research questions that cannot be effectively addressed by a single discipline or method alone. They thus contribute to NFDI’s goal to make a significant contribution to answering novel interdisciplinary research questions. This paper presents some examples for multidisciplinary use-cases that illustrate that, in order to reap the added benefits of these use-cases, some effort is required. The paper concludes by proposing some cornerstones for handling multidisciplinary use-cases.