In this study, the dissolution of a single oxygen bubble on a solid surface, here Titanium alloy Ti64, in ultrapure water with different oxygen undersaturation levels is investigated. For that purpose, a combination of shadowgraph technique and planar laser-induced fluorescence is used to measure simultaneously the changes in bubble geometry and in the dissolved oxygen concentration around the bubble. Two different wettabilities of the Ti64 surface are adjusted by using plasma-enhanced chemical vapor deposition. The dissolution process on the solid surface involves two distinct phases, namely bouncing of the oxygen bubble at the Ti64 surface and the subsequent dissolution of the bubble, primarily by diffusion. By investigating the features of oxygen bubbles bouncing, it was found that the boundary layer of dissolved oxygen surrounding the bubble surface is redistributed by the vortices emerging during bouncing. This establishes the initial conditions for the subsequent second dissolution phase of the oxygen bubbles on the Ti64 surfaces. In this phase, the mass transfer of O₂ proceeds non-homogeneously across the bubble surface, leading to an oxygen accumulation close to the Ti64 surface. We further show that the main factor influencing the differences in the dynamics of O₂ bubble dissolution is the variation in the surface area of the bubbles available for mass transfer, which is determined by the substrate wettability. As a result, dissolution proceeds faster at the hydrophilic Ti64 surface due to the smaller contact angle, which provokes a larger surface area.