When dealing with current and past landscape evolution, a key issue addresses responses of geomorphic systems to the large number of influencing variables. Identifying morphodynamic phases and revealing interrelations with specific driving forces are demanding tasks for Quaternary research. In this paper, we present late Pleistocene and Holocene fluvial sedimentation patterns of three Western Mediterranean river catchments, namely Jarama River, Guadalete River and Guadalquivir River that extent along a climatic transect from semi-humid SW-Spain to semi-arid central Spain. These studies are based on extensive fieldwork conducted on 36 exposures and 13 drillings in floodplain positions. Field data is supported by geochemical analyses, while the chronological framework was obtained from the analyses of 70 radiocarbon samples. Results show distinct patterns of fluvial sedimentation as well as soil formation linked to floodplain stability for each river catchment. On regional or catchment scale, pollen stratigraphical correlation and comparison with lacustrine records show that fluvial dynamics have a strong reaction to climatic shifts, with phases of high fragility characterized by catchment erosion and floodplain sedimentation in response to climatic aridification events and phases of climate change in general. The comparison of the examined river systems reveals that periods of supra-regional floodplain sedimentation in several catchments occurred from 8.0 to 7.0, 5.0 to 3.8, 2.2 to 1.5, and around 1.0 as well as 0.4ka cal. BP, while we found periods of supra-regional soil formation from 13.3 to 12.7, 7.0 to 5.1 (with a short interruption around 6.0 to 5.5ka), 2.8 to 2.3ka, 1.4 to 1.2ka, and 0.8 to 0.5ka cal. BP. Beside these consistencies we found deviating dynamic patterns that are apparently expressed in terms of differing onset and offset, differing durations, or even the lack of fluvial system response. The main reasons for this can be seen in different regional climate condition and impacts of further influencing factors, or in different levels of sensitivity of the river catchments that may be controlled by initial hydrological conditions, catchment size, or the degree of anthropogenic influence. A larger scale assessment shows that fluvial dynamic patterns are hardly comparable across entire Spain due to strong spatial heterogeneity of physiographic and climatic conditions on the Iberian Peninsula, in particular when areas are influenced by different circulation systems (e.g. regions influenced by the Atlantic Ocean vs. regions influenced by the Mediterranean Sea). However, the consideration of North Atlantic marine records reveals a certain coupling between North Atlantic coolings, atmospheric processes leading to arid climate over large parts of Spain, as well as increased landscape instability including strong fluvial sedimentation activity. Attendant atmospheric conditions are discussed.