Verbal Learning and Memory Deficits across Neurological and Neuropsychiatric Disorders: Insights from an ENIGMA Mega Analysis

Publikation: Beitrag in FachzeitschriftForschungsartikelBeigetragenBegutachtung

Beitragende

  • Collaborators - (Autor:in)
  • Psychosoziale Medizin und Entwicklungsneurowissenschaften
  • Klinik und Poliklinik für Kinder- und Jugendpsychiatrie
  • University of Utah
  • US Department of Veterans Affairs
  • Pennsylvania State University
  • Stanford University
  • Dalhousie University
  • Sisters Hospitallers Research Foundation
  • CIBER - Red de Salud Mental
  • Universitat Internacional de Catalunya
  • University of Otago
  • New Zealand Brain Research Institute
  • Health New Zealand | Te Whatu Ora
  • Hospital General Universitario Gregorio Marañon
  • University of California at Los Angeles
  • Universität zu Lübeck
  • Hospital Universitario Marques de Valdecilla
  • IRCCS Fondazione Santa Lucia - Roma
  • Monash University
  • Royal Melbourne Hospital
  • Philipps-Universität Marburg
  • Feinstein Institutes for Medical Research
  • Deakin University
  • Emory University
  • Kessler Foundation
  • Rutgers - The State University of New Jersey, Newark
  • National Institutes of Health (NIH)
  • Hospital Universitario Virgen del Rocio
  • University of Canterbury
  • Icahn School of Medicine at Mount Sinai
  • Westfälische Wilhelms-Universität Münster
  • Alfred Health
  • Florey Institute of Neuroscience and Mental Health
  • University of Minnesota System
  • University of Pittsburgh
  • University of Oregon
  • University of California at San Diego
  • Universitätsklinikum Frankfurt
  • Institut Pere Mata
  • Universidad Rovira i Virgili
  • Seoul National University
  • University of Bergen
  • Haukeland University Hospital
  • Nationwide Children’s Hospital
  • Ohio State University
  • Universität Bern

Abstract

Deficits in memory performance have been linked to a wide range of neurological and neuropsychiatric conditions. While many studies have assessed the memory impacts of individual conditions, this study considers a broader perspective by evaluating how memory recall is differentially associated with nine common neuropsychiatric conditions using data drawn from 55 international studies, aggregating 15,883 unique participants aged 15–90. The effects of dementia, mild cognitive impairment, Parkinson’s disease, traumatic brain injury, stroke, depression, attention-deficit/hyperactivity disorder (ADHD), schizophrenia, and bipolar disorder on immediate, short-, and long-delay verbal learning and memory (VLM) scores were estimated relative to matched healthy individuals. Random forest models identified age, years of education, and site as important VLM covariates. A Bayesian harmonization approach was used to isolate and remove site effects. Regression estimated the adjusted association of each clinical group with VLM scores. Memory deficits were strongly associated with dementia and schizophrenia (p < 0.001), while neither depression nor ADHD showed consistent associations with VLM scores (p > 0.05). Differences associated with clinical conditions were larger for longer delayed recall duration items. By comparing VLM across clinical conditions, this study provides a foundation for enhanced diagnostic precision and offers new insights into disease management of comorbid disorders.

Details

OriginalspracheEnglisch
Aufsatznummer669
FachzeitschriftBrain sciences
Jahrgang14
Ausgabenummer7
PublikationsstatusVeröffentlicht - Juli 2024
Peer-Review-StatusJa

Externe IDs

ORCID /0000-0003-2132-4445/work/203813430

Schlagworte

ASJC Scopus Sachgebiete

Schlagwörter

  • attention-deficit/hyperactivity disorder, bipolar disorder, dementia, depression, memory, Parkinson’s disease, schizophrenia, stroke, traumatic brain injury, verbal learning