Load bearing masonry system is still widely used in many countries, especially for residential units and low-rise office buildings due to their advantages over framed structures. However, analyzing such slabs using hand-calculation-based methods is considered challenging, given that such methods were either developed numerically for framed concrete structures or have limitation that restrict spacial design considerably. And although, such slabs can be analyzed using the finite element method; however, access to such software might be costly for standalone engineers and small firms. In addition, codes of practice recommend checking the results of the FEM software using hand calculations. Therefore, this paper aims to propose a simplified moment distribution-based method for the analysis of two-way concrete slabs supported by masonry walls. The moment distribution method was adjusted for the analysis of two-way concrete slabs using a parametric study that was performed utilizing the finite element analysis. The method has no limitations in terms of the geometry of the structures, as it can be used regardless of the length and arrangement of slab panels. To assess the accuracy of the proposed model, a concrete slab was analyzed as an example using the proposed model and the finite element method. The results obtained from the proposed model were compared with that obtained from the finite element model, and they have revealed that the proposed model is capable of capturing the behavior of the slab with good accuracy.