Underlying mechanisms in the relationship between stress and alcohol consumption in regular and risky drinkers (MESA): methods and design of a randomized laboratory study

Publikation: Beitrag in FachzeitschriftForschungsartikelBeigetragenBegutachtung


  • Charlotte Wittgens - , MSH Medical School Hamburg (Autor:in)
  • Markus Muehlhan - , MSH Medical School Hamburg (Autor:in)
  • Anja Kräplin - , Seniorprofessor für Suchtforschung (Autor:in)
  • Max Wolff - , MIND Foundation, Charité – Universitätsmedizin Berlin (Autor:in)
  • Sebastian Trautmann - , MSH Medical School Hamburg (Autor:in)


Background: Excessive alcohol consumption and alcohol use disorders (AUD) are among the leading preventable causes of premature morbidity and mortality and are considered a major public health concern. In order to reduce the individual and societal burden of excessive alcohol use, it is crucial to identify high-risk individuals at earlier stages and to provide effective interventions to prevent further progression. Stressful experiences are important risk factors for excessive alcohol consumption and AUDs. However, the underlying biological and psychological mechanisms are still poorly understood.
Methods: The project “Underlying mechanisms in the relationship between stress and alcohol consumption in
regular and risky drinkers (MESA)” is a randomized controlled study that started in December 2018 and is conducted in a laboratory setting, which aims to identify moderators and mediators of the relationship between acute stress and alcohol consumption among regular and risky drinkers. Regular and risky drinkers are randomly assigned to a stress induction or a control condition. Several processes that may mediate (emotional distress, endocrine and autonomic stress reactivity, impulsivity, inhibitory control, motivational sensitization) or moderate (trait impulsivity, childhood maltreatment, basal HPA-axis activity) the relation between stress and alcohol consumption are investigated. As primary dependent variable, the motivation to consume alcohol following psychosocial stress is measured.
Discussion: The results of this study could help to provide valuable targets for future research on tailored interventions to prevent stress-related alcohol consumption.


FachzeitschriftBMC Psychology
Frühes Online-Datum15 Okt. 2022
PublikationsstatusVeröffentlicht - Dez. 2022

Externe IDs

Scopus 85139888336
PubMed 36243742
Mendeley ae56bb40-4631-371f-8264-905853c1c06f
unpaywall 10.1186/s40359-022-00942-1
WOS 000868380300001


Forschungsprofillinien der TU Dresden

Fächergruppen, Lehr- und Forschungsbereiche, Fachgebiete nach Destatis

Ziele für nachhaltige Entwicklung

ASJC Scopus Sachgebiete


  • AUD, Acute stress, Ad-libitum taste-test, Risky alcohol consumption, TSST, Impulsive Behavior, Ethanol, Motivation, Alcoholism/psychology, Humans, Alcohol Drinking/psychology, PSYCHOMETRIC PROPERTIES, CHILDHOOD MALTREATMENT, SOCIAL DRINKERS, DRUG-USE, SALIVARY CORTISOL, INTERNAL RELIABILITY, INHIBITORY CONTROL, INCREASES ATTENTIONAL BIAS, USE DISORDERS, LIFE EVENTS