Two major metabolites of 8-prenylnaringenin are estrogenic in vitro

Publikation: Beitrag in FachzeitschriftForschungsartikelBeigetragenBegutachtung

Beitragende

Abstract

8-prenylnaringenin (8-PN) and preparations containing 8-prenylnaringenin have been suggested for use in medicinal and cosmetic applications like hormone replacement or bust enhancement. However, the safety of application is still under considerable debate. Recently it has been shown that human liver microsomes are converting 8-prenylnaringenin to 12 metabolites, with (E)-8-(4''-hydroxyisopentenyl)naringenin (8-PN-OH) and (E)-8-(4''-oxoisopentenyl)naringenin (8-PN=O) being among the most abundant. Applying two independent in vitro test systems we demonstrate that these two metabolites of 8-prenylnaringenin are estrogenic in vitro. These results represent an important piece of information towards the discussion of safety of use of preparations containing 8-prenylnaringenin.

Details

OriginalspracheEnglisch
Seiten (von - bis)107-110
Seitenumfang4
FachzeitschriftJournal of Steroid Biochemistry and Molecular Biology
Jahrgang92
Ausgabenummer1-2
PublikationsstatusVeröffentlicht - Sept. 2004
Peer-Review-StatusJa

Externe IDs

Scopus 8444232577
PubMed 15544936
WOS 000225823100011

Schlagworte

Schlagwörter

  • Flavanones/chemistry, Humulus/chemistry, Molecular Structure, Phytoestrogens/chemistry, Plant Extracts/chemistry