This brief presents an overview of recent tools and research efforts aimed at enhancing the programmability and reliability of In-Memory Computing (IMC)-based systems. We discuss hardware-aware training techniques that improve model resilience to analog device imperfections, and explore mapping strategies that balance accuracy and performance for heterogeneous IMC-based accelerators. Additionally, we examine a compiler framework that abstracts hardware complexities and enables seamless integration of these accelerators into existing deployment pipelines. By combining these approaches with advanced simulation tools, we propose an end-to-end workflow that facilitates the practical deployment and optimization of IMC technologies across diverse memory types and architectural designs.