Tissue macrophage identity and self-renewal

Publikation: Beitrag in FachzeitschriftÜbersichtsartikel (Review)Beigetragen

Beitragende

  • Rebecca Gentek - , INSERM - Institut national de la santé et de la recherche médicale (Autor:in)
  • Kaaweh Molawi - (Autor:in)
  • Michael H Sieweke - , Aix-Marseille Université, INSERM - Institut national de la santé et de la recherche médicale, Centre national de la recherche scientifique (CNRS), Max-Delbrück-Centrum für Molekulare Medizin (MDC) (Autor:in)

Abstract

Macrophages are cellular components of the innate immune system that reside in virtually all tissues and contribute to immunity, repair, and homeostasis. The traditional view that all tissue-resident macrophages derive from the bone marrow through circulating monocyte intermediates has dramatically shifted recently with the observation that macrophages from embryonic progenitors can persist into adulthood and self-maintain by local proliferation. In several tissues, however, monocytes also contribute to the resident macrophage population, on which the local environment can impose tissue-specific macrophage functions. These observations have raised important questions: What determines resident macrophage identity and function, ontogeny or environment? How is macrophage proliferation regulated? In this review, we summarize the current knowledge about the identity, proliferation, and turnover of tissue-resident macrophages and how they differ from freshly recruited short-lived monocyte-derived cells. We examine whether macrophage proliferation can be qualified as self-renewal of mature differentiated cells and whether the concepts and molecular pathways are comparable to self-renewal mechanisms in stem cells. Finally, we discuss how improved understanding of macrophage identity and self-renewal could be exploited for therapeutic intervention of macrophage-mediated pathologies by selectively targeting freshly recruited or resident macrophages.

Details

OriginalspracheEnglisch
Seiten (von - bis)56-73
Seitenumfang18
FachzeitschriftImmunological reviews
Jahrgang262
Ausgabenummer1
PublikationsstatusVeröffentlicht - Nov. 2014
Peer-Review-StatusNein
Extern publiziertJa

Externe IDs

Scopus 84911077979

Schlagworte

Schlagwörter

  • Animals, Cell Differentiation, Cell Proliferation, Humans, Macrophages/cytology, Organ Specificity, Phenotype