The spinal ependymal zone as a source of endogenous repair cells across vertebrates

Publikation: Beitrag in FachzeitschriftÜbersichtsartikel (Review)BeigetragenBegutachtung

Beitragende

  • Catherina G. Becker - , University of Edinburgh (Autor:in)
  • Thomas Becker - , University of Edinburgh (Autor:in)
  • Jean Philippe Hugnot - , University of Edinburgh, CHU Montpellier, Université de Montpellier (Autor:in)

Abstract

Spinal cord injury results in the loss of neurons and axonal connections. In mammals, including humans, this loss is permanent, but is repaired in other vertebrates, such as salamanders and fishes. Cells in the ependymal niche play a pivotal role for the outcome after injury. These cells initiate proliferation and generate new neurons of different types in regenerating species, but only glial cells, contributing to the glial scar, in mammals. Here we compare the cellular and molecular properties of ependymal zone cells and their environment across vertebrate classes. We point out communalities and differences between vertebrates capable of neuronal regeneration and those that are not. Comparisons like these may ultimately lead to the identification of factors that tip the balance for ependymal zone cells in mammals to produce appropriate neural cells for endogenous repair after spinal cord injury.

Details

OriginalspracheEnglisch
Seiten (von - bis)67-80
Seitenumfang14
Fachzeitschrift Progress in neurobiology : an international review journal
Jahrgang170
PublikationsstatusVeröffentlicht - Nov. 2018
Peer-Review-StatusJa
Extern publiziertJa

Externe IDs

PubMed 29649499

Schlagworte

ASJC Scopus Sachgebiete

Schlagwörter

  • Adult neurogenesis, Cilia, CSF-contacting neurons, Ependymal cells, Ependymo-radial glia, Evolutionary comparison, Foxj1, Regeneration, Spinal cord