Accessibility research has matured over the last three decades and developed a better understanding of accessibility technologies, design and evaluation methods, systems and tools as well as empirical studies in accessibility. We envision how progress in new contexts over the next decade can be made to develop stronger links to other areas in Human-Centered Computing and address the research communities. A human-centered perspective on disability needs to develop from a medical model to a social model. New methods will utilize generative AI in design and development processes that address accessibility from the start of system design. We build on AI embedded into future design processes to address participation of small numbers of users better, and new technologies to allow for personalization of multi-modal interaction to improve verbal and non-verbal communication, making body-centric computing and natural interaction truly accessible.