The impact of tumor associated macrophages on tumor biology under the lens of mathematical modelling: A review

Publikation: Beitrag in FachzeitschriftForschungsartikelBeigetragenBegutachtung


In this article, we review the role of mathematical modelling to elucidate the impact of tumor-associated macrophages (TAMs) in tumor progression and therapy design. We first outline the biology of TAMs, and its current application in tumor therapies, and their experimental methods that provide insights into tumor cell-macrophage interactions. We then focus on the mechanistic mathematical models describing the role of macrophages as drug carriers, the impact of macrophage polarized activation on tumor growth, and the role of tumor microenvironment (TME) parameters on the tumor-macrophage interactions. This review aims to identify the synergies between biological and mathematical approaches that allow us to translate knowledge on fundamental TAMs biology in addressing current clinical challenges.

Titel in Übersetzung
Die Auswirkungen von tumorassoziierten Makrophagen auf die Tumorbiologie unter dem Blickwinkel der mathematischen Modellierung: Ein Überblick


FachzeitschriftFrontiers in Immunology
PublikationsstatusVeröffentlicht - 10 Nov. 2022

Externe IDs

Scopus 85142631588
unpaywall 10.3389/fimmu.2022.1050067
Mendeley e56313f4-7b30-3ab7-bd82-b5b5e07953b8
PubMed 36439180
ORCID /0000-0003-3298-3315/work/142245791
ORCID /0000-0002-1270-7885/work/142250324


Forschungsprofillinien der TU Dresden


  • Biology, Macrophages, Models, Theoretical, Tumor Microenvironment, Tumor-Associated Macrophages