The impact of diabetes mellitus on the outcome of troponin-positive patients with non-obstructive coronary arteries

Publikation: Beitrag in FachzeitschriftForschungsartikelBeigetragenBegutachtung

Beitragende

  • Fabienne Kreimer - , Katholisches Klinikum Bochum gGmbH (Autor:in)
  • Clara Schlettert - , BG Universitätsklinikum Bergmannsheil Bochum (Autor:in)
  • Mohammad Abumayyaleh - , Universitätsmedizin Mannheim (Autor:in)
  • Ibrahim Akin - , Universitätsmedizin Mannheim (Autor:in)
  • Mido Max Hijazi - , Klinik und Poliklinik für Neurochirurgie (Autor:in)
  • Nazha Hamdani - , Ruhr-Universität Bochum (Autor:in)
  • Michael Gotzmann - , Katholisches Klinikum Bochum gGmbH (Autor:in)
  • Andreas Mügge - , BG Universitätsklinikum Bergmannsheil Bochum (Autor:in)
  • Ibrahim El-Battrawy - , Ruhr-Universität Bochum (Autor:in)
  • Assem Aweimer - , BG Universitätsklinikum Bergmannsheil Bochum (Autor:in)

Abstract

BACKGROUND: Diabetes mellitus is a major cardiovascular risk factor for the development of coronary artery disease, but knowledge about the impact of diabetes mellitus on the outcome of patients with myocardial infarction with non-obstructive coronary arteries is limited. The aim of this study was to investigate the prognostic impact of diabetes mellitus on in- and out-of-hospital adverse events in troponin-positive patients with non-obstructive coronary arteries.

METHODS AND RESULTS: A total of 373 troponin-positive patients with non-obstructive coronary arteries between 2010 and 2021 at Bergmannsheil University Hospital Bochum were enrolled, including 65 diabetics and 307 nondiabetics. The median follow-up was 6.2 years. The primary study end point was a composite of in-hospital major adverse cardiovascular events (MACE). Secondary endpoints covered MACE during follow-up.Mean age of the study cohort was 62.9 years and 49.3 % were male. Although the overall rate of in-hospital MACE was higher in diabetics (41.5 %) than in non-diabetics (33.9 %), this difference did not reach statistical significance (p = 0.240). The in-hospital mortality rate was low in both groups, 0 % of diabetes group versus 2.9 % of non-diabetic patients. During follow-up, diabetic patients had a significantly higher rate of MACE (51.9 % vs. 31.1 %, p = 0.004) and a significantly higher all-cause mortality rate than non-diabetic patients (42.3 % vs. 20.1 %, p < 0.001).

CONCLUSION: Our study reveals that the impact of diabetes mellitus on cardiovascular outcomes in troponin-positive patients with non-obstructive coronary arteries intensifies over the long term, leading to increased rates of both cardiovascular adverse events and overall mortality.

Details

OriginalspracheEnglisch
Aufsatznummer101350
Fachzeitschrift International journal of cardiology. Heart and Vasculature
Jahrgang50
PublikationsstatusVeröffentlicht - Feb. 2024
Peer-Review-StatusJa

Externe IDs

PubMedCentral PMC10847989
Scopus 85184072875

Schlagworte

Ziele für nachhaltige Entwicklung