The F-actin bundler SWAP-70 promotes tumor metastasis.

Publikation: Beitrag in FachzeitschriftForschungsartikelBeigetragenBegutachtung

Abstract

Dynamic rearrangements of the F-actin cytoskeleton are a hallmark of tumor metastasis. Thus, proteins that govern F-actin rearrangements are of major interest for understanding metastasis and potential therapies. We hypothesized that the unique F-actin binding and bundling protein SWAP-70 contributes importantly to metastasis. Orthotopic, ectopic, and short-term tail vein injection mouse breast and lung cancer models revealed a strong positive dependence of lung and bone metastasis on SWAP-70. Breast cancer cell growth, migration, adhesion, and invasion assays revealed SWAP-70's key role in these metastasis-related cell features and the requirement for SWAP-70 to bind F-actin. Biophysical experiments showed that tumor cell stiffness and deformability are negatively modulated by SWAP-70. Together, we present a hitherto undescribed, unique F-actin modulator as an important contributor to tumor metastasis.

Details

OriginalspracheEnglisch
Aufsatznummere202302307
Seiten (von - bis)1-18
Seitenumfang18
FachzeitschriftLife Science Alliance
Jahrgang7
Ausgabenummer8
PublikationsstatusVeröffentlicht - 17 Mai 2024
Peer-Review-StatusJa

Externe IDs

PubMed 38760173
ORCID /0000-0003-1181-3659/work/160049796
ORCID /0000-0001-7687-0983/work/160049979
ORCID /0000-0002-2433-916X/work/160479913
Scopus 85193633830

Schlagworte

Schlagwörter

  • Breast cancer, Cell adhesion, Cell migration, F-actin, Metastasis, SWAP-70, Cell Movement/genetics, Actin Cytoskeleton/metabolism, Actins/metabolism, Breast Neoplasms/pathology, Humans, Microfilament Proteins/metabolism, Cell Adhesion/genetics, Neoplasm Metastasis, Animals, Lung Neoplasms/metabolism, Cell Line, Tumor, Protein Binding, Female, Cell Proliferation/genetics, Mice