The duration, magnitude and compartmentalization of ERK MAP kinase activity: mechanisms for providing signaling specificity

Publikation: Beitrag in FachzeitschriftForschungsartikelBeigetragenBegutachtung

Beitragende

  • Miki Ebisuya - , Kyoto University (Autor:in)
  • Kunio Kondoh - (Autor:in)
  • Eisuke Nishida - (Autor:in)

Abstract

ERK MAP kinase signaling plays a pivotal role in diverse cellular functions, including cell proliferation, differentiation, migration and survival. One of the central questions concerning this signaling is how activation of the same protein kinase, ERK, elicits distinct cellular outcomes. Recent progress has demonstrated that differences in the duration, magnitude and subcellular compartmentalization of ERK activity generate variations in signaling output that regulate cell fate decisions. Furthermore, several molecules have been identified as spatial, temporal or strength-controlling regulators of ERK activity. Signaling by various extracellular stimuli thus could be modulated by these regulators to give qualitative and quantitative differences in ERK activity, which are then interpreted by the cells as determinants for appropriate responses.

Details

OriginalspracheEnglisch
Seiten (von - bis)2997-3002
Seitenumfang6
FachzeitschriftJournal of cell science
Jahrgang118
AusgabenummerPt 14
PublikationsstatusVeröffentlicht - 15 Juli 2005
Peer-Review-StatusJa
Extern publiziertJa

Externe IDs

Scopus 23844494402

Schlagworte

Schlagwörter

  • Animals, Cell Nucleus/enzymology, Enzyme Activation, Extracellular Signal-Regulated MAP Kinases/metabolism, MAP Kinase Signaling System/physiology, Subcellular Fractions/enzymology