The associations of Positive and Negative Valence Systems, Cognitive Systems and Social Processes on disease severity in anxiety and depressive disorders

Publikation: Beitrag in FachzeitschriftForschungsartikelBeigetragenBegutachtung


  • Bernd R Förstner - , Universität Potsdam (Autor:in)
  • Sarah Jane Böttger - , Universität Potsdam (Autor:in)
  • Alexander Moldavski - , Zentralinstitut für Seelische Gesundheit (ZI) (Autor:in)
  • Malek Bajbouj - , Charité – Universitätsmedizin Berlin (Autor:in)
  • Andrea Pfennig - , Klinik und Poliklinik für Psychiatrie und Psychotherapie (Autor:in)
  • André Manook - , Universitätsklinikum Regensburg (Autor:in)
  • Marcus Ising - , Max Planck Institute of Psychiatry (Autor:in)
  • Andre Pittig - , Institut für Klinische Psychologie und Psychotherapie, Universitätsmedizin Göttingen (Autor:in)
  • Ingmar Heinig - , Institut für Klinische Psychologie und Psychotherapie (Autor:in)
  • Andreas Heinz - , Charité – Universitätsmedizin Berlin (Autor:in)
  • Klaus Mathiak - , RWTH Aachen University (Autor:in)
  • Thomas G Schulze - , SUNY Upstate Medical University, Johns Hopkins Medicine, Klinikum der Ludwig-Maximilians-Universität (LMU) München (Autor:in)
  • Frank Schneider - , RWTH Aachen University (Autor:in)
  • Inge Kamp-Becker - , Universitätsklinikum Gießen und Marburg GmbH (Autor:in)
  • Andreas Meyer-Lindenberg - , Zentralinstitut für Seelische Gesundheit (ZI) (Autor:in)
  • Frank Padberg - , Klinikum der Ludwig-Maximilians-Universität (LMU) München (Autor:in)
  • Tobias Banaschewski - , Zentralinstitut für Seelische Gesundheit (ZI) (Autor:in)
  • Michael Bauer - , Klinik und Poliklinik für Psychiatrie und Psychotherapie (Autor:in)
  • Rainer Rupprecht - , Universitätsklinikum Regensburg (Autor:in)
  • Hans-Ulrich Wittchen - , Institut für Klinische Psychologie und Psychotherapie, Klinikum der Ludwig-Maximilians-Universität (LMU) München (Autor:in)
  • Michael A Rapp - , Universität Potsdam (Autor:in)
  • Mira Tschorn - , Universität Potsdam (Autor:in)


BACKGROUND: Anxiety and depressive disorders share common features of mood dysfunctions. This has stimulated interest in transdiagnostic dimensional research as proposed by the Research Domain Criteria (RDoC) approach by the National Institute of Mental Health (NIMH) aiming to improve the understanding of underlying disease mechanisms. The purpose of this study was to investigate the processing of RDoC domains in relation to disease severity in order to identify latent disorder-specific as well as transdiagnostic indicators of disease severity in patients with anxiety and depressive disorders.

METHODS: Within the German research network for mental disorders, 895 participants (n = 476 female, n = 602 anxiety disorder, n = 257 depressive disorder) were recruited for the Phenotypic, Diagnostic and Clinical Domain Assessment Network Germany (PD-CAN) and included in this cross-sectional study. We performed incremental regression models to investigate the association of four RDoC domains on disease severity in patients with affective disorders: Positive (PVS) and Negative Valance System (NVS), Cognitive Systems (CS) and Social Processes (SP).

RESULTS: The results confirmed a transdiagnostic relationship for all four domains, as we found significant main effects on disease severity within domain-specific models (PVS: β = -0.35; NVS: β = 0.39; CS: β = -0.12; SP: β = -0.32). We also found three significant interaction effects with main diagnosis showing a disease-specific association.

LIMITATIONS: The cross-sectional study design prevents causal conclusions. Further limitations include possible outliers and heteroskedasticity in all regression models which we appropriately controlled for.

CONCLUSION: Our key results show that symptom burden in anxiety and depressive disorders is associated with latent RDoC indicators in transdiagnostic and disease-specific ways.


FachzeitschriftFrontiers in psychiatry
Jahrgang14 (2023)
PublikationsstatusVeröffentlicht - 16 Juni 2023

Externe IDs

PubMedCentral PMC10313476
Scopus 85164432584
ORCID /0000-0002-3415-5583/work/150329744
ORCID /0000-0002-7762-4327/work/150329767
ORCID /0000-0002-2666-859X/work/150329163


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