Stimuli-responsive hydrogels combine sensor and actuator properties by converting an environmental stimulus into mechanical work. Those materials are highly interesting for applications as a chemomechanical valve in microsystem technologies. However, studies about key characteristics of hydrogels for this application are comparatively rare, and further research is needed to emphasize their real potential. The first part of this study depicts the synthesis of grafted hydrogels based on a poly(N-isopropylacrylamide) backbone and pH-sensitive poly(acrylic acid) graft chains. The chosen approach of grafted hydrogels provides the preparation of multiresponsive hydrogels, which retain temperature sensitivity besides being pH-responsive. A pronounced salt and solvent response is additionally achieved. Key characteristics for an application as a chemomechanical valve of the graft hydrogels are revealed: (1 …