Synthetic developmental biology: build and control multicellular systems

Publikation: Beitrag in FachzeitschriftÜbersichtsartikel (Review)BeigetragenBegutachtung

Beitragende

  • Mo R Ebrahimkhani - , Arizona State University, Mayo Clinic College of Medicine and Science (Autor:in)
  • Miki Ebisuya - , European Molecular Biology Laboratory (EMBL) Barcelona (Autor:in)

Abstract

Synthetic biology offers a bottom-up engineering approach that intends to understand complex systems via design-build-test cycles. Embryonic development comprises complex processes that originate at the level of gene regulatory networks in a cell and emerge into collective cellular behaviors with multicellular forms and functions. Here, we review synthetic biology approaches to development that involve building de novo developmental trajectories or engineering control in stem cell-derived multicellular systems. The field of synthetic developmental biology is rapidly growing with the help of recent advances in artificial gene circuits, self-organizing organoids, and controllable tissue microenvironments. The outcome will be a blueprint to decode principles of morphogenesis and to create programmable organoids with novel designs or improved functions.

Details

OriginalspracheEnglisch
Seiten (von - bis)9-15
Seitenumfang7
FachzeitschriftCurrent opinion in chemical biology
Jahrgang52
PublikationsstatusVeröffentlicht - Okt. 2019
Peer-Review-StatusJa
Extern publiziertJa

Externe IDs

Scopus 85065542438

Schlagworte

Schlagwörter

  • Cell Communication, Developmental Biology, Embryonic Development, Gene Regulatory Networks, Morphogenesis, Organoids, Stem Cells/cytology, Synthetic Biology