Synthesis and radiofluorination of iodophenyl esters as tool for the traceless staudinger ligation
Publikation: Beitrag in Fachzeitschrift › Forschungsartikel › Beigetragen › Begutachtung
Beitragende
Abstract
A new synthetic pathway for the preparation of ω-functionalized 2-iodophenyl esters as starting materials for the synthesis of substituted phosphanes is described. A radiolabeling of these esters with fluorine-18 has led to building blocks which were reacted with HPPh2 in a Pd-catalyzed P-C cross coupling to establish new phosphanes. These compounds can be applied as mild and bioorthogonal radiolabeling agents by means of the traceless Staudinger ligation. A route to access this class of compounds has been established.
Details
Originalsprache | Englisch |
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Seiten (von - bis) | 1128-1136 |
Seitenumfang | 9 |
Fachzeitschrift | Zeitschrift fur Naturforschung - Section B Journal of Chemical Sciences |
Jahrgang | 65 |
Ausgabenummer | 9 |
Publikationsstatus | Veröffentlicht - 2010 |
Peer-Review-Status | Ja |
Externe IDs
ORCID | /0000-0002-6432-5694/work/151982354 |
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Schlagworte
ASJC Scopus Sachgebiete
Schlagwörter
- Bioorthogonal, PET, Radiofluorination, Staudinger Ligation, Traceless, X-Ray Structure