Survival after secondary liver resection in metastatic colorectal cancer: Comparing data of three prospective randomized European trials (LICC, CELIM, FIRE‐3)

Publikation: Beitrag in FachzeitschriftForschungsartikelBeigetragenBegutachtung

Beitragende

  • Markus Moehler - (Autor:in)
  • Gunnar Folprecht - , Medizinische Klinik und Poliklinik I (Autor:in)
  • Volker Heinemann - (Autor:in)
  • Julian Walter Holch - (Autor:in)
  • Annett Maderer - (Autor:in)
  • Stefan Kasper - (Autor:in)
  • Susanna Hegewisch‐Becker - (Autor:in)
  • Jan Schröder - (Autor:in)
  • Friedrich Overkamp - (Autor:in)
  • Frank Kullmann - (Autor:in)
  • Wolf Otto Bechstein - (Autor:in)
  • Matthias Vöhringer - (Autor:in)
  • Robert Öllinger - (Autor:in)
  • Florian Lordick - (Autor:in)
  • Michael Geißler - , Hochschulmedizin (Medizinische Fakultät und Universitätsklinikum) (Autor:in)
  • Armin Schulz‐Abelius - (Autor:in)
  • Bernhard Linz - (Autor:in)
  • Helga Bernhard - (Autor:in)
  • Andreas Paul - (Autor:in)
  • Irene Schmidtmann - (Autor:in)
  • Karin Potthoff - (Autor:in)
  • Carl Christoph Schimanski - (Autor:in)

Abstract

Metastatic colorectal cancer (mCRC) patients with liver-limited disease (LLD) have a chance of long-term survival and potential cure after hepatic metastasectomy. However, the appropriate postoperative treatment strategy is still controversial. The CELIM and FIRE-3 studies demonstrated that secondary hepatic resection significantly improved overall survival (OS). The objective of this analysis was to compare these favorable outcome data with recent results from the LICC trial investigating the antigen-specific cancer vaccine tecemotide (L-BLP25) as adjuvant therapy in mCRC patients with LLD after R0/R1 resection. Data from mCRC patients with LLD and secondary hepatic resection from each study were analyzed for efficacy outcomes based on patient characteristics, treatment and surveillance after surgery. In LICC, 40/121 (33%) patients, in CELIM 36/111 (32%) and in FIRE-3-LLD 29/133 (22%) patients were secondarily resected, respectively. Of those, 31 (77.5%) patients in LICC and all patients in CELIM were R0 resected. Median disease-free survival after resection was 8.9 months in LICC, 9.9 months in CELIM. Median OS in secondarily resected patients was 66.1 months in LICC, 53.9 months in CELIM and 56.2 months in FIRE-3-LLD. Median age was about 5 years less in LICC compared to CELIM and FIRE-3. Secondarily resected patients of LICC, CELIM and FIRE-3 showed an impressive median survival with a tendency for improved survival for patients in the LICC trial. A younger patient cohort but also more selective surgery, improved resection techniques, deep responses and a close surveillance program after surgery in the LICC trial may have had a positive impact on survival.

Details

OriginalspracheEnglisch
Seiten (von - bis)1341-1349
Seitenumfang9
FachzeitschriftInternational journal of cancer
Jahrgang150
Ausgabenummer8
PublikationsstatusVeröffentlicht - 15 Apr. 2022
Peer-Review-StatusJa

Externe IDs

Scopus 85120888937
Mendeley 4cb698ff-f31b-3d3b-a284-d10dc771e29e

Schlagworte

Ziele für nachhaltige Entwicklung