Surfactant administration during endotracheal CPAP: Feasibility, risk factors for failure and short-term outcomes of DD-SURF

Publikation: Beitrag in FachzeitschriftForschungsartikelBeigetragenBegutachtung

Beitragende

Abstract

Aim: Whereas there is agreement that surfactant should be administered without mechanical ventilation, there is still a debate concerning the optimal method. DD-SURF combines the benefits of INSURE and less invasive surfactant administration (LISA). The efficacy of this approach has not been evaluated yet. Methods: Retrospective cohort study of all preterm newborns below 300/7 weeks gestational age admitted to the neonatal intensive care unit. Data on surfactant therapy, respiratory support during the first 96 h of life and neonatal morbidities until hospital discharge were collected from the electronic patient charts to evaluate the efficacy and safety of our approach. Results: In total, 222 newborns met the inclusion criteria; 174 (78%) received surfactant in the delivery room by the DD-SURF procedure and 21 infants (10%) were not extubated after surfactant administration (Surf-and-vent group). After DD-SURF, 75% of patients did not require reintubation. Intraventricular haemorrhage and bronchopulmonary dysplasia occured more often in infants after DD-SURF failure than after successful DD-SURF. Conclusion: DD-SURF potentially combines the benefits of INSURE and LISA and represents a useful alternative of surfactant delivery with comparable success rates to thin-catheter surfactant administration.

Details

OriginalspracheEnglisch
Seiten (von - bis)1653-1658
Seitenumfang6
FachzeitschriftActa Paediatrica, International Journal of Paediatrics
Jahrgang112
Ausgabenummer8
PublikationsstatusVeröffentlicht - Aug. 2023
Peer-Review-StatusJa

Externe IDs

PubMed 36946356
ORCID /0000-0002-2586-8987/work/143074850
WOS 000962190700001

Schlagworte

Schlagwörter

  • extremely preterm newborn, respiratory distress syndrome, surfactant, Respiratory distress syndrome, Extremely preterm newborn, Surfactant, Continuous Positive Airway Pressure, Surface-Active Agents/therapeutic use, Respiratory Distress Syndrome, Newborn/drug therapy, Humans, Risk Factors, Feasibility Studies, Pulmonary Surfactants/therapeutic use, Infant, Premature, Respiration, Artificial/adverse effects, Retrospective Studies, Infant, Newborn

Bibliotheksschlagworte