Stress and salivary telomere length in the second half of life: A comparison of life-course models

Publikation: Beitrag in FachzeitschriftForschungsartikelBeigetragenBegutachtung

Beitragende

  • Margaret Willis - , Columbia University (Autor:in)
  • Ursula M. Staudinger - , Columbia University (Autor:in)
  • Pam Factor-Litvak - , Columbia University (Autor:in)
  • Esteban Calvo - , Columbia University, Universidad Mayor (Autor:in)

Abstract

Background: Previous research has explored the relationship between childhood and adulthood stressful life events (SLEs) and adult salivary telomere length (TL), but no research to date has tested different life-course models in which stress in adulthood may fully, partly, or not mediate the relationship between childhood stress and adult TL. Methods: To fill this gap, we elaborate over previous work by Puterman et al. (2016) and other standard models that do not account for the temporal order of stressors in childhood and adulthood, by using structural equation modeling (SEM) for a sample of 5754 Health and Retirement Study (HRS) participants to compare the fit of three nested life-course models—social trajectory, early critical period, and cumulative risk. Results: Results indicated that the social trajectory model, in which the association between childhood SLEs and TL in later adulthood is fully mediated by adulthood SLEs, fit the data better than the early critical period (no mediation) and cumulative risk (partial mediation) models. Conclusion: In the social trajectory model, childhood SLEs are related to TL in later life only through adulthood SLEs. The direct physiological effect of childhood SLEs on TL in later life would be overestimated if adulthood SLEs are overlooked.

Details

OriginalspracheEnglisch
Seiten (von - bis)34-41
Seitenumfang8
FachzeitschriftAdvances in Life Course Research
Jahrgang39
PublikationsstatusVeröffentlicht - 12 Feb. 2019
Peer-Review-StatusJa
Extern publiziertJa

Externe IDs

PubMed 31186623

Schlagworte

Schlagwörter

  • Gender, Life cycle, Mediation, Stressful life events, Trauma

Bibliotheksschlagworte