State-Dependent Functional Dysconnectivity in Youth With Psychosis Spectrum Symptoms

Publikation: Beitrag in FachzeitschriftForschungsartikelBeigetragenBegutachtung

Beitragende

  • Eva Mennigen - , Klinik und Poliklinik für Psychiatrie und Psychotherapie, University of California at Irvine, Semel Inst Neurosci & Human Behav (Autor:in)
  • Dietsje D. Jolles - , University of California at Irvine (Autor:in)
  • Catherine E. Hegarty - , University of California at Irvine (Autor:in)
  • Mohan Gupta - , University of California at Irvine (Autor:in)
  • Maria Jalbrzikowski - , University of Pittsburgh (Autor:in)
  • Loes M. Olde Loohuis - , University of California at Irvine (Autor:in)
  • Roel A. Ophoff - , University of California at Irvine (Autor:in)
  • Katherine H. Karlsgodt - , University of California at Irvine (Autor:in)
  • Carrie E. Bearden - , University of California at Irvine (Autor:in)

Abstract

Psychosis spectrum disorders are conceptualized as neurodevelopmental disorders accompanied by disruption of large-scale functional brain networks. Dynamic functional dysconnectivity has been described in patients with schizophrenia and in help-seeking individuals at clinical high risk for psychosis. Less is known, about developmental aspects of dynamic functional network connectivity (dFNC) associated with psychotic symptoms (PS) in the general population. Here, we investigate resting state functional magnetic resonance imaging data using established dFNC methods in the Philadelphia Neurodevelopmental Cohort (ages 8-22 years), including 129 participants experiencing PS and 452 participants without PS (non-PS). Functional networks were identified using group spatial independent component analysis. A sliding window approach and k-means clustering were applied to covariance matrices of all functional networks to identify recurring whole-brain connectivity states. PS-associated dysconnectivity of default mode, salience, and executive networks occurred only in a few states, whereas dysconnectivity in the sensorimotor and visual systems in PS youth was more pervasive, observed across multiple states. This study provides new evidence that disruptions of dFNC are present even at the less severe end of the psychosis continuum in youth, complementing previous work on help-seeking and clinically diagnosed cohorts that represent the more severe end of this spectrum.

Details

OriginalspracheEnglisch
Seiten (von - bis)408-421
Seitenumfang14
FachzeitschriftSchizophrenia bulletin
Jahrgang46
Ausgabenummer2
PublikationsstatusVeröffentlicht - März 2020
Peer-Review-StatusJa

Externe IDs

PubMed 31219595
Scopus 85081161459
ORCID /0000-0001-5099-0274/work/142249105

Schlagworte

Schlagwörter

  • Adolescence, Dynamic functional network connectivity, Independent component analysis, Psychosis spectrum