Smoking, tobacco dependence, and neurometabolites in the dorsal anterior cingulate cortex

Publikation: Beitrag in FachzeitschriftForschungsartikelBeigetragenBegutachtung

Beitragende

  • Joseph O’Neill - , University of California at Los Angeles (Gemeinsame:r Erstautor:in)
  • Maylen Perez Diaz - , University of California at Los Angeles, Biogen (Gemeinsame:r Erstautor:in)
  • Jeffry R. Alger - , University of California at Los Angeles (Autor:in)
  • Jean Baptiste Pochon - , University of California at Los Angeles (Autor:in)
  • Dara Ghahremani - , University of California at Los Angeles (Autor:in)
  • Andrew C. Dean - , University of California at Los Angeles (Autor:in)
  • Rachel F. Tyndale - , University of Toronto (Autor:in)
  • Nicole Petersen - , University of California at Los Angeles (Autor:in)
  • Shane Marohnic - , University of California at Los Angeles (Autor:in)
  • Andrea Karaiskaki - , University of California at Los Angeles (Autor:in)
  • Edythe D London - , University of California at Los Angeles (Autor:in)

Abstract

Cigarette smoking has a major impact on global health and morbidity, and positron emission tomographic research has provided evidence for reduced inflammation in the human brain associated with cigarette smoking. Given the consequences of inflammatory dysfunction for health, the question of whether cigarette smoking affects neuroinflammation warrants further investigation. The goal of this project therefore was to validate and extend evidence of hypoinflammation related to smoking, and to examine the potential contribution of inflammation to clinical features of smoking. Using magnetic resonance spectroscopy, we measured levels of neurometabolites that are putative neuroinflammatory markers. N-acetyl compounds (N-acetylaspartate + N-acetylaspartylglutamate), glutamate, creatine, choline-compounds (phosphocholine + glycerophosphocholine), and myo-inositol, have all been linked to neuroinflammation, but they have not been examined as such with respect to smoking. We tested whether people who smoke cigarettes have brain levels of these metabolites consistent with decreased neuroinflammation, and whether clinical features of smoking are associated with levels of these metabolites. The dorsal anterior cingulate cortex was chosen as the region-of-interest because of previous evidence linking it to smoking and related states. Fifty-four adults who smoked daily maintained overnight smoking abstinence before testing and were compared with 37 nonsmoking participants. Among the smoking participants, we tested for associations of metabolite levels with tobacco dependence, smoking history, craving, and withdrawal. Levels of N-acetyl compounds and glutamate were higher, whereas levels of creatine and choline compounds were lower in the smoking group as compared with the nonsmoking group. In the smoking group, glutamate and creatine levels correlated negatively with tobacco dependence, and creatine correlated negatively with lifetime smoking, but none of the metabolite levels correlated with craving or withdrawal. The findings indicate a link between smoking and a hypoinflammatory state in the brain, specifically in the dorsal anterior cingulate cortex. Smoking may thereby increase vulnerability to infection and brain injury.

Details

OriginalspracheEnglisch
Seiten (von - bis)4756-4765
Seitenumfang10
FachzeitschriftMolecular psychiatry
Jahrgang28
Ausgabenummer11
PublikationsstatusVeröffentlicht - Nov. 2023
Peer-Review-StatusJa
Extern publiziertJa

Externe IDs

PubMed 37749232
PubMedCentral PMC10914613
ORCID /0009-0007-0589-3679/work/173989314