Skin-conformable photoplethysmogram (PPG) sensors enable continuous and accurate monitoring of physiological states to efficiently prevent cardiovascular-related diseases. Herein, novel PPG sensors consisting of polymer/oxide hybrid phototransistors, mini-light-emitting diodes, and a framework conformable to epidermis are developed. The key element, a heterojunction phototransistor for efficient energy usage, is composed of an indium gallium zinc oxide (IGZO)-based active layer for low-power consumption and a specific diketopyrrolopyrrole (DPP) polymer layer affording high near-infrared (NIR) light absorbability and hydrophobicity. Therefore, the phototransistors with NIR detectivity of 1.00 × 10¹³ Jones, rapid photoresponse within the human heart rate range, high reliability against perspiration and mechanical stress, and low operating voltages (< 5 V) are achieved. Using the developed PPG sensors, the heart rate and oxygen saturation of human subjects are successfully detected, which is comparable to the commercial PPG sensors. Furthermore, controlling potential barrier energy at the interface between heterojunction layers, PPG sensors that operate separately at low and high heart rates are implemented for continuous monitoring. Consequently, a distinguished configuration of skin-conformable PPG sensors and a novel concept of an always-on cardiovascular monitoring system while consuming less power are suggested. The study contributes to the development of PPG sensors and may become a potential solution for Healthcare 4.0 applications.