Signaling protein SWAP-70 is required for efficient B cell homing to lymphoid organs
Publikation: Beitrag in Fachzeitschrift › Forschungsartikel › Beigetragen › Begutachtung
Beitragende
Abstract
The migration of B cells into secondary lymphoid organs is required for the generation of an effective immune response. Here we analyzed the involvement of SWAP-70, a Rac-interacting protein involved in actin rearrangement, in B cell entry into lymph nodes. We noted reduced migration of Swap70-/- B cells into lymph nodes in vivo. Swap70-/- B cells rolled and adhered, yet accumulated in lymph node high endothelial venules. This defect was not due to impaired integrin expression or chemotaxis. Instead, Swap70-/- B cells aberrantly regulated integrin-mediated adhesion. During attachment, Swap70-/- B cells showed defective polarization and did not form uropods or stabilize lamellipodia at a defined region. Thus, SWAP-70 selectively regulates processes essential for B cell entry into lymph nodes.
Details
Originalsprache | Englisch |
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Seiten (von - bis) | 827-834 |
Seitenumfang | 8 |
Fachzeitschrift | Nature Immunology |
Jahrgang | 7 |
Ausgabenummer | 8 |
Publikationsstatus | Veröffentlicht - Aug. 2006 |
Peer-Review-Status | Ja |
Externe IDs
Scopus | 33746107576 |
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researchoutputwizard | legacy.publication#13410 |
PubMed | 16845395 |
Schlagworte
Schlagwörter
- Animals, B-Lymphocytes/cytology, Cell Movement/immunology, DNA-Binding Proteins/immunology, Guanine Nucleotide Exchange Factors/immunology, Lymph Nodes/cytology, Lymphocyte Activation/immunology, Mice, Minor Histocompatibility Antigens, Nuclear Proteins/immunology, Receptors, Lymphocyte Homing/immunology