Serotonergic neurotransmission in early Parkinson's disease: a pilot study to assess implications for depression in this disorder.
Publikation: Beitrag in Fachzeitschrift › Forschungsartikel › Beigetragen › Begutachtung
Abstract
Objectives. Depression, a disease usually accompanied by a serotonergic deficit, has been observed in about 40% of patients suffering from Parkinson's disease (PD). Thus, a serotonergic dysfunction in PD can be assumed. We aimed to investigate the interaction between serotonergic (5-HT) and dopaminergic activity in early PD. We hypothesized a serotonergic as well as a dopaminergic deficit in PD patients. We also assumed a correlation between these neurotransmitters indicating a relationship between dopaminergic and serotonergic function in PD. Methods. Nine unmedicated PD patients before and 12 weeks after l-dopa treatment and nine healthy subjects were examined using the loudness dependence of auditory evoked potentials (LDAEP), a promising indicator of central serotonergic function. Dopaminergic transporters (DAT) were collected using 123I-FP-CIT and single photon emission computer tomography (SPECT). LDAEP values were correlated with 123I-FP-CIT SPECT data. Results. A significant difference between LDAEP of controls and patients (P= 0.05) suggested lower serotonergic activity in PD. Twelve weeks after initiation of l-dopa treatment this difference was lost between patients and controls (P= 0.20). There was a trend towards a correlation between LDAEP and DAT (r= 0.65; P = 0.057) of the unmedicated patients, suggesting a low serotonergic activity may be related to a dopamine deficit in PD. Conclusions. Our results support the hypothesis that serotonergic neurotransmission is decreased in untreated PD and suggest that a low serotonergic activity may be related to the dopamine pathology in PD. This could be related to the high prevalence of depression in PD.
Details
Originalsprache | Englisch |
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Seiten (von - bis) | 781-787 |
Seitenumfang | 7 |
Fachzeitschrift | World Journal of Biological Psychiatry |
Jahrgang | 11 |
Ausgabenummer | 6 |
Publikationsstatus | Veröffentlicht - 2010 |
Peer-Review-Status | Ja |
Externe IDs
Scopus | 77955615920 |
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ORCID | /0000-0002-8845-8803/work/161406394 |