Self-organization and cooperativity of weakly coupled molecular motors under unequal loading

Publikation: Beitrag in FachzeitschriftForschungsartikelBeigetragenBegutachtung

Beitragende

  • Jan Brugués - , University of Barcelona, ESPCI (Autor:in)
  • Jaume Casademunt - , University of Barcelona (Autor:in)

Abstract

We study the collective dynamics of Brownian motors moving on a one-dimensional track when an external load is applied to the leading motor. Motors are driven by a two-state ratchet mechanism, which is appropriate to single-headed kinesins, and their relative motion is only constrained by their mutual interaction potential (weak coupling). We show that unequal loading enhances cooperativity, leading to the formation of clusters with velocities and efficiencies higher than those predicted by simple superposition. When a weak attraction between motors is present, we find nonmonotonic collective velocity-force curves, hysteretic phenomena, and a dynamic self-regulation mechanism that selects the cluster size for optimal performance.

Details

OriginalspracheEnglisch
Aufsatznummer118104
FachzeitschriftPhysical review letters
Jahrgang102
Ausgabenummer11
PublikationsstatusVeröffentlicht - 17 März 2009
Peer-Review-StatusJa
Extern publiziertJa

Schlagworte

ASJC Scopus Sachgebiete