Roadmap for Condensates in Cell Biology

Publikation: Beitrag in Fachzeitschrift › Forschungsartikel › Beigetragen › Begutachtung

Beitragende

  • Dilimulati Aierken - , Princeton University (Autor:in)
  • Sebastian Aland - , Technische Universität Bergakademie Freiberg, Hochschule für Technik und Wirtschaft (HTW) Dresden (Autor:in)
  • Stefano Bo - , King's College London (KCL) (Autor:in)
  • Steven Boeynaems - , Baylor College of Medicine, Texas Children's Hospital Houston (Autor:in)
  • Danfeng Cai - , Johns Hopkins University, Johns Hopkins Medicine (Autor:in)
  • Serena Carra - , University of Modena and Reggio Emilia (Autor:in)
  • Lindsay B. Case - , Massachusetts Institute of Technology (MIT) (Autor:in)
  • Hue Sun Chan - , University of Toronto (Autor:in)
  • Jorge R. Espinosa - , Universidad Complutense de Madrid, University of Cambridge (Autor:in)
  • Trevor K. Grandpre - , Washington University St. Louis, The University of Chicago (Autor:in)
  • Alexander Y. Grosberg - , New York University (Autor:in)
  • Ivar S. Haugerud - , Universität Augsburg (Autor:in)
  • William M. Jacobs - , Princeton University (Autor:in)
  • Jerelle A. Joseph - , Princeton University (Autor:in)
  • Frank Jülicher - , Max-Planck-Institut für Physik komplexer Systeme, Exzellenzcluster PoL: Physik des Lebens (Autor:in)
  • Kurt Kremer - , Max-Planck-Institut für Polymerforschung (Autor:in)
  • Guido Kusters - , Max Planck Institute for Dynamics and Self-Organization (Autor:in)
  • Liedewij Laan - , Technische Universität Delft (Autor:in)
  • Keren Lasker - , University of Florida (Autor:in)
  • Kathrin S. Laxhuber - , Max-Planck-Institut für Physik komplexer Systeme (Autor:in)
  • Hyun O. Lee - , University of Toronto (Autor:in)
  • Kathy F. Liu - , University of Pennsylvania Perelman School of Medicine, University of Pennsylvania (Autor:in)
  • Dimple Notani - , Tata Institute of Fundamental Research (Autor:in)
  • Yicheng Qiang - , Max Planck Institute for Dynamics and Self-Organization (Autor:in)
  • Paul Robustelli - , Dartmouth College (Autor:in)
  • Leonor Saiz - , University of California at Davis (Autor:in)
  • Omar A. Saleh - , University of California at Santa Barbara (Autor:in)
  • Helmut Schiessel - , Exzellenzcluster PoL: Physik des Lebens, Professur für Theoretische Physik Lebender Materie (PoL) (Autor:in)
  • Jeremy D. Schmit - , Kansas State University (Autor:in)
  • Meng Shen - , California State University Fullerton (Autor:in)
  • Krishna Shrinivas - , Northwestern University (Autor:in)
  • Antonia Statt - , University of Illinois at Urbana-Champaign (Autor:in)
  • Andres R. Tejedor - , Universidad Complutense de Madrid, University of Cambridge (Autor:in)
  • Tatjana Trcek - , Johns Hopkins University (Autor:in)
  • Christoph A. Weber - , Universität Augsburg (Autor:in)
  • Stephanie C. Weber - , McGill University (Autor:in)
  • Ned S. Wingreen - , Princeton University (Autor:in)
  • Huaiying Zhang - , Carnegie Mellon University (Autor:in)
  • Yaojun Zhang - , Johns Hopkins University, Johns Hopkins Medicine (Autor:in)
  • Huan Xiang Zhou - , University of Illinois at Chicago (Autor:in)
  • David Zwicker - , Max Planck Institute for Dynamics and Self-Organization (Autor:in)

Abstract

Biomolecular condensates govern essential cellular processes yet elude description by traditional equilibrium models. This roadmap, distilled from structured discussions at a workshop and reflecting the consensus of its participants, clarifies key concepts for researchers, funding bodies, and journals. After unifying terminology that often separates disciplines, we outline the core physics of condensate formation, review their biological roles, and identify outstanding challenges in nonequilibrium theory, multiscale simulation, and quantitative in-cell measurements. We close with a forward-looking outlook to guide coordinated efforts toward predictive, experimentally anchored understanding and control of biomolecular condensates.

Details

OriginalspracheEnglisch
Aufsatznummer032501
FachzeitschriftPRX Life
Jahrgang4
Ausgabenummer3
PublikationsstatusVeröffentlicht - 1 Juli 2026
Peer-Review-StatusJa

Schlagworte

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