Background: Psychosocial stress, overtime, shift work, long sitting times and noise are known as occupational factors in the wide range of risks for cardiovascular diseases (CVD). Due to unfavourable risk profiles, prevention is focused on blue collar employees. Data on the distribution of individual and occupational risk factors among managers is contradictory. Objective: The aim of the study was to demonstrate differences in the distribution of clinical and subclinical parameters and traditional and occupational risk factors for the occurrence of cardiovascular diseases among managers compared to non-managers. Methods: The study was based on 8,175 gainfully employed participants in the baseline survey of the Gutenberg Health Study (GHS) in Mainz and the Mainz-Bingen district (age 35 to 64 years). The classification of participants as a manager was based on the current job code, as coded by the German classification of occupations KldB 2010. Regression models were applied to compare the clinical and subclinical parameters and traditional and occupational risk factors among managerial and non-managerial staff. Models were adjusted for age, job complexity level and occupational area and stratified by gender. Results: 15.5% of gainfully employed subjects (n = 1,270) worked as managers (21.1% of the men, 8.8% of the women). The proportion of smokers and obese persons, the total working hours and the number of overtime hours were higher among managers. Fibrinogen and hs-CRP levels were higher in female managers. In male managers there was evidence of increased occurrence of hypertension. Conclusion: Managers showed less favourable risk profiles for CVD. Approaches for prevention activities in managers should focus on individual changes, e.g. in the reduction of body weight and nicotine consumption, as well as occupational aspects.