Renal elimination of beta-2-microglobulin and myoglobin in patients with normal and impaired renal function
Publikation: Beitrag in Fachzeitschrift › Forschungsartikel › Beigetragen › Begutachtung
Beitragende
Abstract
Since the demonstration that β2-microglobulin (β2M) is an amyloidogenic protein in man, the excretion of this low-molecular-weight protein under conditions with normal and reduced function has received increased interest. The renal arteriovenous extraction of β2M, polyfructosan (an inulin analogue), and a second low-molecular-weight protein, myoglobin, was measured in vivo in 16 human kidneys with normal renal function/gross morphology and in 22 kidneys with reduced function. In kidneys with normal function, the extraction of β2M significantly exceeded that of polyfructosan (0.198 ± 0.037 vs 0.182 ± 0.05; p = 0.04), while that of myoglobin (0.177 ± 0.068) was not different from that of polyfructosan. In kidneys with reduced function, the extraction of polyfructosan or myoglobin was not significantly altered. In contrast, the β2M extraction decreased to 0.110 ± 0.060 (p<0.01 vs. extraction of polyfructosan or myoglobin). This decrease was significantly correlated with the decrease of the endogenous creatinine clearance or the total or unilateral 131I-hippuran clearance. These results indicate that in normal renal function the glomerular filtration of β2M may be supplemented by a peritubular mode of removal. The mechanisms(s) underlying the selective decrease of β2M extraction in kidneys with reduced function remain speculative. However, this decrease will lead to a further augmentation of the retention of β2M in renal failure.
Details
Originalsprache | Englisch |
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Seiten (von - bis) | 361-367 |
Seitenumfang | 7 |
Fachzeitschrift | Nephron |
Jahrgang | 55 |
Ausgabenummer | 4 |
Publikationsstatus | Veröffentlicht - 1990 |
Peer-Review-Status | Ja |
Extern publiziert | Ja |
Externe IDs
PubMed | 2202918 |
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Schlagworte
ASJC Scopus Sachgebiete
Schlagwörter
- Low-molecular-weight proteins, Myoglobin, β-Microglobulin