Regulation of cerebral cortex size and folding by expansion of basal progenitors

Publikation: Beitrag in FachzeitschriftForschungsartikelBeigetragenBegutachtung

Beitragende

  • Miki Nonaka-Kinoshita - , Technische Universität Dresden (Autor:in)
  • Isabel Reillo - , Miguel Hernández University (Autor:in)
  • Benedetta Artegiani - , Technische Universität Dresden (Autor:in)
  • Maria Ángeles Martínez-Martínez - , Miguel Hernández University (Autor:in)
  • Mark Nelson - , Echelon Biosciences (Autor:in)
  • Víctor Borrell - , Miguel Hernández University (Autor:in)
  • Federico Calegari - , Center for Regenerative Therapies Dresden (CRTD) (Autor:in)

Abstract

Size and folding of the cerebral cortex increased massively during mammalian evolution leading to the current diversity of brain morphologies. Various subtypes of neural stem and progenitor cells have been proposed to contribute differently in regulating thickness or folding of the cerebral cortex during development, but their specific roles have not been demonstrated. We report that the controlled expansion of unipotent basal progenitors in mouse embryos led to megalencephaly, with increased surface area of the cerebral cortex, but not to cortical folding. In contrast, expansion of multipotent basal progenitors in the naturally gyrencephalic ferret was sufficient to drive the formation of additional folds and fissures. In both models, changes occurred while preserving a structurally normal, six-layered cortex. Our results are the first experimental demonstration of specific and distinct roles for basal progenitor subtypes in regulating cerebral cortex size and folding during development underlying the superior intellectual capability acquired by higher mammals during evolution.

Details

OriginalspracheEnglisch
Seiten (von - bis)1817-1828
Seitenumfang12
FachzeitschriftEMBO Journal
Jahrgang32
Ausgabenummer13
PublikationsstatusVeröffentlicht - 3 Juli 2013
Peer-Review-StatusJa

Externe IDs

PubMed 23624932

Schlagworte

Schlagwörter

  • Basal progenitors, Brain evolution, Mammalian neural stem cells, Mouse brain development, Neurogenesis