The paper presents a substantial review of the use of reduced graphene oxide (rGO)-based electrochemical sensors. rGO, a physicochemical derivative of graphene, is a pivotal carbon nanostructure for multimodal sensing applications. The high electrical conductivity and excellent charge-transfer properties enabled rGO to be functionalized and integrated to form efficient electrochemical sensors. It has been integrated with other nanomaterials to increase the overall selectivity and specificity of the resultant nanocomposites towards the target molecule. Rhodamine B is one of the toxic dyes used as a colouring agent in various food products. Detecting this chemical in food products is necessary because its accumulation has detrimental effects on human health. The paper highlights the capability of rGO-based composite sensors to detect Rhodamine B molecules. The research examples presented here have been divided into two groups based on the conjugation of rGO with metal oxides and non-metal oxides. It also shows the ability of the graphene-based sensors to remove Rhodamine B from contaminated real-time samples. Finally, the paper highlights the limitations of current sensors, potential remedies, and future trajectories for these sensors.