Redox- and pH-Responsive Polymersomes with Ferrocene Moieties Exhibiting Peroxidase-like, Chemoenzymatic Activity and H<sub>2</sub>O<sub>2</sub>-Responsive Release Behavior

Publikation: Beitrag in FachzeitschriftForschungsartikelBeigetragenBegutachtung


  • Silvia Moreno - , Leibniz Institute of Polymer Research Dresden (Autor:in)
  • Hanna Huebner - , Universität des Saarlandes (Autor:in)
  • Christiane Effenberg - , Leibniz Institute of Polymer Research Dresden (Autor:in)
  • Susanne Boye - , Leibniz Institute of Polymer Research Dresden (Autor:in)
  • Anthony Ramuglia - , Professur für Elektrochemie, Technische Universität Dresden (Autor:in)
  • Deborah Schmitt - , Universität des Saarlandes (Autor:in)
  • Brigitte Voit - , Professur für Organische Chemie der Polymere (gB/IPF) (MTC3), Leibniz Institute of Polymer Research Dresden, Technische Universität Dresden (Autor:in)
  • Inez M. Weidinger - , Professur für Elektrochemie, Technische Universität Dresden (Autor:in)
  • Markus Gallei - , Universität des Saarlandes (Autor:in)
  • Dietmar Appelhans - , Leibniz Institute of Polymer Research Dresden (Autor:in)


The development of compartments for the design of cascade reactions in a local space requires a selective spatiotemporal control. The combination of enzyme-loaded polymersomes with enzymelike units shows a great potential in further refining the diffusion barrier and the type of reactions in nanoreactors. Herein, pH-responsive and ferrocene-containing block copolymers were synthesized to realize pH-stable and multiresponsive polymersomes. Permeable membrane, peroxidaselike behavior induced by the redox-responsive ferrocene moieties and release properties were validated using cyclovoltammetry, dye TMB assay, and rupture of host-guest interactions with beta-cyclodextrin, respectively. Due to the incorporation of different block copolymers, the membrane permeability of glucose oxidase-loaded polymersomes was changed by increasing extracellular glucose concentration and in TMB assay, allowing for the chemoenzymatic cascade reaction. This study presents a potent synthetic, multiresponsive nanoreactor platform with tunable (e.g., redox-responsive) membrane properties for potential application in therapeutics.


Seiten (von - bis)4655-4667
PublikationsstatusVeröffentlicht - 14 Nov. 2022

Externe IDs

PubMed 36215725
Scopus 85141933696
ORCID /0000-0002-4531-691X/work/148608043



  • Block-copolymers, Drug-delivery, Fenton reaction, Ferric ions, Nanocarriers, Nanoreactors, Oxidation, Membrane, Nanocontainers, Polymerization