Raman Spectroscopy of Optically Trapped Living Human T Cell Subsets and Monocytes

Publikation: Beitrag in FachzeitschriftForschungsartikelBeigetragenBegutachtung

Beitragende

Abstract

In recent years, Raman spectroscopy has garnered growing interest in the field of biomedical research. It offers a non-invasive and label-free approach to defining the molecular fingerprint of immune cells. We utilized Raman spectroscopy on optically trapped immune cells to investigate their molecular compositions. While numerous immune cell types have been studied in the past, the characterization of living human CD3/CD28-stimulated T cell subsets remains incomplete. In this study, we demonstrate the capability of Raman spectroscopy to readily distinguish between naïve and stimulated CD4 and CD8 cells. Additionally, we compared these cells with monocytes and discovered remarkable similarities between stimulated T cells and monocytes. This paper contributes to expanding our knowledge of Raman spectroscopy of immune cells and serves as a launching point for future clinical applications.

Details

OriginalspracheEnglisch
Aufsatznummer9557
FachzeitschriftInternational journal of molecular sciences
Jahrgang25
Ausgabenummer17
PublikationsstatusVeröffentlicht - 3 Sept. 2024
Peer-Review-StatusJa

Externe IDs

Scopus 85204022578
ORCID /0000-0001-8799-8202/work/171553696

Schlagworte