There is a lack of information about the effect of climate change on the water budget for the eastern side of Colombia, which is currently experiencing an increased pressure on its water resources due to the demand for food, industrial use, and human demand for drinking and hygiene. In this study, the lumped model BROOK90 was utilized with input based on the available historical and projected meteorological data, as well as land use and soil information. With this data, we were able to determine the changes in the water balance components in four different regions, representing four different water districts in Eastern Colombia. These four regions reflect four different sets of climate and geographic conditions. The projected data were obtained using the Statistical Downscaling Model (SDSM), in which two global climate models were used in addition to two different climate scenarios from each. These are the Representative Concentration Pathways (RCP) RCP 2.6 and RCP 8.5. Results showed that the temporal and spatial distribution of water balance components were considerably affected by the changing climate. A reduction in the generated streamflow for all of the studied regions is shown and changes in the evapotranspiration and stored water were varied for each region according to both the climate scenario as well as the characteristics of soil and land use for each area. The results of spatial change of the water balance components showed a direct link to the geography of each region. Soil moisture was reduced considerably in the next decades, and the percentage of decrease varied for each scenario