The aetiology of low back pain is complex and multidimensional. Physical and (partially) psychosocial occupational factors seem to play an important aetiological role. In this article, the evidence for specific primary and secondary prevention and intervention strategies - which are derived from the analysis of risk factors for low back pain - is summarized. Multidimensional interventions focussing on the workplace as well as on the affected individual have proven to effectively influence the occurrence and the course of low back pain. There is a need for additional high-quality randomized controlled studies - particularly focussing on workplace interventions - and for a continuous evaluation of existing prevention and intervention strategies.