Nowadays, zeotropic mixtures with a temperature glide up to 15 K are the state of the art in air-conditioning. Less attention is paid to mixtures with larger temperature glides (LTG). The small number of research activities can be explained by the lack of promising applications as refrigerants in cooling applications. However, these glides can be beneficial for heat pump applications and Organic Rankine Cycles (ORC), since these systems mainly operate with sensible heat sources and heat sinks. The paper points out the potentials of LTG working fluids in heat pumps and ORC and discusses fluid combinations for different temperature levels. The limits of these applications are identified, an overview about challenges reported in the literature are presented and the advantages are demonstrated. Especially a new kind of ORC is presented, which operates as a heat transformer integrated in an industrial heat recovery system.