Objectives: Advances in molecular medicine and genetic testing will increase the provision of presymptomatic gene tests. The utilisation of such tests depends on medical and psychosocial factors, e.g. personal attitudes towards genetic testing. The aim of this study was to compare the general attitudes towards genetic testing in the general population and in medical students. Methods: In 2001, we conducted a survey in a representative sample of the German population (N = 2.076). Additionally, we asked N = 129 medical students. Subjects were administered a 13-items questionnaire which was previously used in a Finnish study. The items pertain to approval, disapproval, and concern for genetic testing. Results: The comparison between the medical students and a matched sample from the general population revealed significant differences in the general attitudes towards genetic testing. Medical students showed higher approval of gene tests. However, they also stated more concerns and acknowledged more clearly possible disadvantages of genetic testing. Conclusion: Medical teaching curricula in psychosocial aspects of genetic testing should comprise the issue of attitudes towards genetic testing. Especially, medical students, physicians and other professionals involved in genetic testing and counseling should be cognizant of possible differences in their approval and disapproval of genetic testing compared to their consultants.