Position statement of the German STI Society on the prophylactic use of doxycycline to prevent STIs (Doxy-PEP, Doxy-PrEP)

Publikation: Beitrag in FachzeitschriftForschungsartikelBeigetragenBegutachtung

Beitragende

  • Ricardo Niklas Werner - , Charité – Universitätsmedizin Berlin (Autor:in)
  • Axel Jeremias Schmidt - , London School of Hygiene and Tropical Medicine, Deutche AIDS-Hilfe e.V. (Autor:in)
  • Anja Potthoff - , Ruhr-Universität Bochum, WIR – Walk In Ruhr – Centre for Sexual Health and Medicine (Autor:in)
  • Petra Spornraft-Ragaller - , Klinik und Poliklinik für Dermatologie, Universitätsklinikum Carl Gustav Carus Dresden (Autor:in)
  • Norbert Hermann Brockmeyer - , Ruhr-Universität Bochum (Autor:in)

Abstract

Over the past two decades, there has been a rise in the incidence of syphilis, particularly among men who have sex with men (MSM). This has sparked interest in studying the prophylactic use of doxycycline to prevent syphilis and other sexually transmitted infections (STIs), commonly referred to as Doxycycline Pre- or Post-Exposure Prophylaxis (Doxy-PrEP, Doxy-PEP). At the same time, demand from potential users for this preventive measure is increasing. Several randomized controlled trials have demonstrated that the prophylactic use of doxycycline in MSM and trans women using HIV pre-exposure prophylaxis (HIV-PrEP) or living with an HIV infection effectively reduces the risk of syphilis and chlamydia infections. At present, however, unresolved questions remain, particularly regarding implications of a broad implementation of prophylactic doxycycline to prevent STIs on tetracycline and other antimicrobial resistance in bacterial STIs, non-STI-related bacterial pathogens, and the microbiome. In response to the increasing demand and the challenge of balancing effectiveness, safety, and the risk of promoting antibiotic resistance, the German STI Society (DSTIG) has issued a position statement, providing specific recommendations regarding potential indications, criteria, and occasions for the use of doxycycline in STI prevention. These recommendations are based on current evidence and expert opinion.

Details

OriginalspracheEnglisch
Seitenumfang13
FachzeitschriftJournal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG
Jahrgang22
Ausgabenummer3
Frühes Online-Datum20 Dez. 2023
PublikationsstatusElektronische Veröffentlichung vor Drucklegung - 20 Dez. 2023
Peer-Review-StatusJa

Externe IDs

Scopus 85180204185

Schlagworte

Ziele für nachhaltige Entwicklung