Polygenic risk score-based phenome-wide association study identifies novel associations for Tourette syndrome

Publikation: Beitrag in FachzeitschriftForschungsartikelBeigetragenBegutachtung

Beitragende

  • Purdue University
  • Vanderbilt University
  • Harvard University
  • Broad Institute of Harvard University and MIT
  • Democritus University of Thrace
  • Aristotle University of Thessaloniki
  • University of Catania
  • Medizinische Hochschule Hannover (MHH)
  • Universität Kopenhagen
  • Sorbonne Université
  • Universität Duisburg-Essen
  • Hospital Universitario Virgen del Rocio
  • CIBER - Centro de Investigación Biomédica en Red
  • Utrecht University
  • Universität Ulm
  • Vrije Universiteit Amsterdam (VU)
  • Medical University of Warsaw
  • Polish Academy of Sciences
  • Semmelweis University
  • Vadaskert Clinic for Child and Adolescent Psychiatry
  • Icahn School of Medicine at Mount Sinai
  • Radboud University Nijmegen
  • deCODE Genetics
  • Boehringer Ingelheim GmbH
  • Tel Aviv University
  • University of Rome La Sapienza
  • King's College London (KCL)
  • Great Ormond Street Hospital for Children NHS Trust
  • Levvel
  • Amsterdam University Medical Centers (UMC)
  • University of Barcelona
  • August Pi i Sunyer Biomedical Research Institute
  • Ludwig-Maximilians-Universität München (LMU)
  • Universität zu Lübeck
  • Université de Lausanne
  • ASL BA
  • University of Zurich
  • University College London
  • University of Calgary

Abstract

Tourette Syndrome (TS) is a complex neurodevelopmental disorder characterized by vocal and motor tics lasting more than a year. It is highly polygenic in nature with both rare and common previously associated variants. Epidemiological studies have shown TS to be correlated with other phenotypes, but large-scale phenome wide analyses in biobank level data have not been performed to date. In this study, we used the summary statistics from the latest meta-analysis of TS to calculate the polygenic risk score (PRS) of individuals in the UK Biobank data and applied a Phenome Wide Association Study (PheWAS) approach to determine the association of disease risk with a wide range of phenotypes. A total of 57 traits were found to be significantly associated with TS polygenic risk, including multiple psychosocial factors and mental health conditions such as anxiety disorder and depression. Additional associations were observed with complex non-psychiatric disorders such as Type 2 diabetes, heart palpitations, and respiratory conditions. Cross-disorder comparisons of phenotypic associations with genetic risk for other childhood-onset disorders (e.g.: attention deficit hyperactivity disorder [ADHD], autism spectrum disorder [ASD], and obsessive-compulsive disorder [OCD]) indicated an overlap in associations between TS and these disorders. ADHD and ASD had a similar direction of effect with TS while OCD had an opposite direction of effect for all traits except mental health factors. Sex-specific PheWAS analysis identified differences in the associations with TS genetic risk between males and females. Type 2 diabetes and heart palpitations were significantly associated with TS risk in males but not in females, whereas diseases of the respiratory system were associated with TS risk in females but not in males. This analysis provides further evidence of shared genetic and phenotypic architecture of different complex disorders.

Details

OriginalspracheEnglisch
Aufsatznummer69
Seiten (von - bis)1-10
Seitenumfang10
FachzeitschriftTranslational psychiatry
Jahrgang13
Ausgabenummer1
PublikationsstatusVeröffentlicht - Dez. 2023
Peer-Review-StatusJa

Externe IDs

PubMed 36823209