Point-of-care tests (PoCTs) enable the rapid diagnosis of sexually transmitted infections (STIs) directly at the point of care and play a central role in achieving the goals of the World Health Organization (WHO) for the global elimination of AIDS and hepatitis and the reduction of STIs by 2030.The European Union's new regulation for in vitro diagnostics raises the quality standards for PoCTs. All STI tests must now undergo more rigorous reviews. Advances in PoCT development have improved testing options for HIV, syphilis, and hepatitis C, particularly through WHO prequalified tests. However, the HIV self-tests available in Germany only detect the antibody component, which means that a negative result is only reliably conclusive 12 weeks after exposure. For syphilis, PoCTs are available for antibody screening, but these still require subsequent laboratory confirmation. For infections with chlamydia, gonococci, and mycoplasma, the quality of PoCTs is still largely inadequate. Further developments in the field of nucleic acid amplification tests (NATs) show promising approaches.PoCTs are particularly beneficial for low-threshold services aimed at marginalized groups, as they enable swift diagnosis and timely treatment within the test setting. However, challenges remain, including quality assurance and potential psychological stress due to false-positive results. There remains a need for continuous development and the integration of PoCTs into the healthcare system in order to improve access to diagnostics and to reduce the spread of infections.