pH-Triggered Aggregate Shape of Different Generations Lysine-Dendronized Maleimide Copolymers with Maltose Shell

Publikation: Beitrag in FachzeitschriftForschungsartikelBeigetragenBegutachtung

Beitragende

  • S. Boye - , Leibniz Institute of Polymer Research Dresden (Autor:in)
  • D. Appelhans - , Leibniz Institute of Polymer Research Dresden (Autor:in)
  • V. Boyko - , Leibniz Institute of Polymer Research Dresden (Autor:in)
  • S. Zschoche - , Leibniz Institute of Polymer Research Dresden (Autor:in)
  • H. Komber - , Leibniz Institute of Polymer Research Dresden (Autor:in)
  • P. Friedel - , Leibniz Institute of Polymer Research Dresden (Autor:in)
  • P. Formanek - , Leibniz Institute of Polymer Research Dresden (Autor:in)
  • A. Janke - , Leibniz Institute of Polymer Research Dresden (Autor:in)
  • B. I. Voit - , Professur für Organische Chemie der Polymere (gB/IPF) (MTC3), Leibniz Institute of Polymer Research Dresden (Autor:in)
  • A. Lederer - , Leibniz Institute of Polymer Research Dresden, Technische Universität Dresden (Autor:in)

Abstract

Glycopolymers are promising materials in the field of biomedical applications and in the fabrication of supramolecular structures with specific functions. For tunable design of supramolecular structures, glycopolymer architectures with specific properties (e.g., controlled self-assembly) are needed. Using the concept of dendronized polymers, a series of H-bond active giant glycomacromolecules with maleimide backbone and lysine dendrons of different generations were synthesized. They possess different macromolecular size and functionality along the backbone. Their peripheral maltose units lead to solubility under physiological conditions and controlled aggregation behavior. The aggregation behavior was investigated depending on generation number, pH value, and concentration. A portfolio of complementary analytical tools give an insight into the influence of the different parameters in shaping a rod-, coil-, and worm-like molecular structure and their controlled aggregate formation. MD simulation helped us to understand the complex aggregation behavior of the linear polymer chain without dendritic units.

Details

OriginalspracheEnglisch
Seiten (von - bis)4222-4235
Seitenumfang14
FachzeitschriftBiomacromolecules
Jahrgang13
Ausgabenummer12
PublikationsstatusVeröffentlicht - Dez. 2012
Peer-Review-StatusJa

Externe IDs

PubMed 23110476
Scopus 84870874542
ORCID /0000-0002-4531-691X/work/148607876

Schlagworte

Schlagwörter

  • Field-flow fractionation, Polyester dendritic systems, Drug-delivery applications, Biological-properties, Polymers, Glycopolymers, Dendrimers, Design, Glycodendrimers, Nanoparticles