The Gilles de la Tourette Syndrome (GTS) is a multifaceted neuropsychiatric disease. The pharmacological Therapy for Tourette's syndrome is very complex. In the present review, we describe essential forms of pharmacological therapy presented in a practical form and indications for pharmacological treatment in Tourette's syndrome. Only with sufficiently long existing, impairing tics, the use of drugs should be considered, since according to current knowledge a pharmacological treatment of tics does not affect the causes of tics and the course of the disease.