PET/MR for therapy response evaluation in malignant lymphoma: initial experience

Publikation: Beitrag in FachzeitschriftForschungsartikelBeigetragenBegutachtung



OBJECT: To evaluate the feasibility of positron emission tomography/magnetic resonance imaging (PET/MR) with (18)fluoro-2-deoxyglucose (FDG) for therapy response evaluation of malignant lymphoma.

MATERIALS AND METHODS: Nine patients with malignant lymphoma who underwent FDG-PET/MR before and after chemotherapy were included in this retrospective study. Average time between the two scans was 70 days. The scans were evaluated independently by two nuclear medicine physicians. The Ann Arbor classification was used to describe lymphoma stage. Furthermore, the readers also rated PET image quality using a five point scale. Weighted kappa (κ) was used to calculate interrater agreement.

RESULTS: The initial scan showed foci of increased FDG uptake in all patients, with Ann Arbor stage varying between I and IV. In the follow-up examination, all but one patient showed complete response to chemotherapy. PET image quality was rated as very good or excellent for all scans. Interrater agreement was excellent regarding Ann Arbor stage (κ = 0.97) and good regarding image quality (κ = 0.41).

CONCLUSION: PET/MR shows promising initial results for therapy response evaluation in lymphoma patients.


Seiten (von - bis)49-55
Fachzeitschrift Magnetic resonance materials in physics, biology and medicine : (MAGMA)
PublikationsstatusVeröffentlicht - Feb. 2013

Externe IDs

Scopus 84874117722
PubMed 22983794
PubMedCentral PMC3572376
researchoutputwizard legacy.publication#55715



  • Adolescent, Adult, Feasibility Studies, Female, Fluorodeoxyglucose F18, Humans, Lymphoma/diagnostic imaging, Magnetic Resonance Imaging/instrumentation, Male, Middle Aged, Neoplasm Staging, Positron-Emission Tomography/instrumentation, Radiopharmaceuticals, Retrospective Studies, Tomography, X-Ray Computed, Treatment Outcome