Periodontal treatment and peripheral arterial disease severity - a retrospective analysis of health insurance claims data

Publikation: Beitrag in FachzeitschriftForschungsartikelBeigetragenBegutachtung


  • Ghazal Aarabi - , Universitätsklinikum Hamburg-Eppendorf (UKE) (Autor:in)
  • Michael Raedel - , Poliklinik für Zahnärztliche Prothetik, Universitätsklinikum Carl Gustav Carus Dresden (Autor:in)
  • Thea Kreutzburg - , Universitätsklinikum Hamburg-Eppendorf (UKE) (Autor:in)
  • Sandra Hischke - , Universitätsklinikum Hamburg-Eppendorf (UKE) (Autor:in)
  • Eike Sebastian Debus - , Universitätsklinikum Hamburg-Eppendorf (UKE) (Autor:in)
  • Ursula Marschall - , BARMER Institut für Gesundheitssystemforschung (bifg) (Autor:in)
  • Udo Seedorf - , Universitätsklinikum Hamburg-Eppendorf (UKE) (Autor:in)
  • Christian-Alexander Behrendt - , Universitätsklinikum Hamburg-Eppendorf (UKE) (Autor:in)


Background: Although epidemiological data suggest an association between periodontitis (PD) and peripheral arterial disease (PAD), it is currently unclear whether treatment of PD influences the severity of PAD. Patients and methods: Whether periodontal treatment is associated with PAD disease severity was examined by analysing health insurance claims data of patients insured by the German health insurance fund, BARMER, between January 1, 2012 and December 31, 2016. The presence of PAD was determined in individuals using International Classification of Diseases (ICD) 10 th revision codes for intermittent claudication (IC) or chronic limb threatening ischaemia (CLTI). Treatment of PD was assessed by adequate ambulatory coding for non-surgical and surgical treatment of PD. Multivariate logistic regression analysis was performed to evaluate the association between PAD stages and periodontal treatment, adjusted for diabetes, age and sex. Results: The study cohort included 70,944 hospitalized patients with a diagnosis of symptomatic PAD (54.99 % women, 49.05 % IC). Among these patients, 3,567 (5.03 %) had received prior treatment for PD by supra- or sub-gingival debridement. PAD patients who had received periodontal treatment showed a lower proportion of CLTI (28.76 % among treated vs. 52.12 % among non-treated). Using multivariable regression methods, exhibiting a CLTI (vs. IC) was associated with not being treated for PD (Odds Ratio 1.97, 95 %-CI 1.83-2.13) after adjustment for age, gender, and diabetes. Conclusions: In this large-scale retrospective analysis of health insurance claims data comprising hospitalized symptomatic PAD patients, treatment of PD was associated with PAD disease severity independent of age, gender and diabetes. A potential benefit of periodontal treatment in relation to PAD will have to be determined in further prospective studies.


Seiten (von - bis)128-132
FachzeitschriftVasa - European Journal of Vascular Medicine
PublikationsstatusVeröffentlicht - März 2020

Externe IDs

Scopus 85080114757
ORCID /0000-0001-5859-2318/work/142254203


Ziele für nachhaltige Entwicklung


  • Female, Humans, Insurance, Health, Male, Peripheral Arterial Disease, Prospective Studies, Retrospective Studies, Risk Factors