For their unique properties, titanium alloys have found wide application in high-tech engineering. But these alloys are difficult to machine and to grind for their high chemical reactivity and poor thermal properties, which aggravate the grinding zone temperature and its detrimental effects. The objective of this article is a comparison of the grindability of Ti-6Al-4V regarding cubic boron nitride (CBN) and diamond brazed type monolayered grinding wheels under the influence of different environments. In grinding this alloy, cryogenic cooling did not help visibly for both CBN and diamond, but the application of oil and also of alkaline coolant significantly gave the best results.