We report the observation of a novel effect in the bilayer Pb-Bi2Sr2CaCu2O8 (Pb-Bi2212) high-Tc superconductor by means of angle-resolved photoemission with circularly polarized excitation. Different scattering rates, determined as a function of energy separately for the bonding and antibonding copper-oxygen bands, strongly imply that the dominating scattering channel is odd with respect to layer exchange within a bilayer. This is inconsistent with a phonon-mediated scattering and favors the participation of the odd collective spin excitations in the scattering mechanism in near-nodal regions of the k space, suggesting a magnetic nature of the pairing mediator.